If you wish to use HW UART instead of the USB cable, it’s perfectly possible … you just need to do a bit more work to free the UART up on your Pi.
To get started, hook the GPS module up to your Pi as follows, cross-connecting the TX and RX pins (TX on one device goes to RX on the other and vice versa), and supply 5V from the Pi to the VIN pin on the GPS module…
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Python for Microcontrollers – Adafruit Daily — Python on Microcontrollers Newsletter: A New Arduino MicroPython Package Manager, How-Tos and Much More! #CircuitPython #Python #micropython @ThePSF @Raspberry_Pi
EYE on NPI – Adafruit Daily — EYE on NPI Maxim’s Himalaya uSLIC Step-Down Power Module #EyeOnNPI @maximintegrated @digikey