0

What Can An Onion Do To Inspire A New Drug Delivery Method? #Biomimicry

How does the biomimicry of an onion inspire a new drug delivery method? via thedrugdeliveryblog

Nature is the greatest architect of all. It has been a driver of innovations and solutions for millions of years. Nature driven design can drive solutions to many of our greatest questions we have today – including better delivering drugs to the right places in better ways then ever before.

Researchers from Penn have taken a lead from nature and discovered a way to simulate an onion structure to deliver drugs in a slow releasing formula. After being challenged by trying to figure out how to replicate a cell membrane, researchers found a dendrimer with vesicles inside that was stable after created in a lab. This allows the scientists to dictate the number of layers and the thickness within the dendrimer. So, with this technology, which peals like an onion, multiple drugs can be housed in one delivery cell and over time the drugs can be released into the blood stream.

How can scientists achieve this feat of production and delivery? Penn News explains:
“By testing different dendrimers with different organic solvents, the research team found they could produce these onion-like vesicles and control the number of layers they contained. By changing the concentration of the dendrimers in the solvent, they could produce vesicles with as many as 20 layers when that solution was introduced to water. And because the layers are consistently spaced, the team could control the overall size of the vesicles by predicting the number of layers they could contain.

To actually see the multilayered structure of their vesicles, the researchers used a technique known as cryogenic transmission electron microscopy, or CryoTEM. This technique can take pictures of objects at the nanoscale floating in aqueous solution. To keep the fluid-floating vesicles in frame, the team flash-froze the sample, locking them in amorphous ice that was free of damaging ice crystals.”

We’ll be talking about these topics and many more in drug delivery innovation at Drug Delivery Partnerships 2015. Next year’s program is currently in the works.

Read more


Stop breadboarding and soldering – start making immediately! Adafruit’s Circuit Playground is jam-packed with LEDs, sensors, buttons, alligator clip pads and more. Build projects with Circuit Playground in a few minutes with the drag-and-drop MakeCode programming site, learn computer science using the CS Discoveries class on code.org, jump into CircuitPython to learn Python and hardware together, or even use Arduino IDE. Circuit Playground Express is the newest and best Circuit Playground board, with support for MakeCode, CircuitPython, and Arduino. It has a powerful processor, 10 NeoPixels, mini speaker, InfraRed receive and transmit, two buttons, a switch, 14 alligator clip pads, and lots of sensors: capacitive touch, IR proximity, temperature, light, motion and sound. A whole wide world of electronics and coding is waiting for you, and it fits in the palm of your hand.

Join 8,500+ makers on Adafruit’s Discord channels and be part of the community! http://adafru.it/discord

CircuitPython – Python on Microcontrollers is here!

Have an amazing project to share? Join the SHOW-AND-TELL every Wednesday night at 7:30pm ET on Google+ Hangouts.

Join us every Wednesday night at 8pm ET for Ask an Engineer!

Follow Adafruit on Instagram for top secret new products, behinds the scenes and more https://www.instagram.com/adafruit/


Maker Business — Rethink Robotics closes shop. Long live collaborative robots #makerbusiness

Wearables — Cleaning is key

Electronics — Serial overkill

Biohacking — Biohacking Resources – Books, Talks and Podcasts

Python for Microcontrollers — CircuitPython @ Hackaday SuperCon #ICYMI @circuitpython @micropython @ThePSF #Python

Get the only spam-free daily newsletter about wearables, running a "maker business", electronic tips and more! Subscribe at AdafruitDaily.com !



No Comments

No comments yet.

Sorry, the comment form is closed at this time.