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Jacqueline Barton #ALD15 @findingada

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Jacqueline Barton is an American chemist who studies the chemical and physical properties of DNA and how they effect biological activity with the potential to help find treatments for cancer. via Wikepedia

Jacqueline Kapelman Barton… worked as a Professor of Chemistry at Hunter College (1980–82), and at Columbia University (1983–89) before joining the California Institute of Technology (1989-to the present). She is currently the Arthur and Marian Hanisch Memorial Professor of Chemistry and Chair of the Division of Chemistry and Chemical Engineering at Caltech.

Barton introduced the application of transition metal complexes to probe recognition and reactions of double helical DNA. She has designed chiral metal complexes which mimic the properties of DNA-binding proteins, allowing other researchers the capability to simulate and analyze experiments in this nature. Barton additionally established that DNA charge transport chemistry is extremely sensitive to intervening perturbations in the DNA base stack, as with single base mismatches or lesions. This discovery has been a cornerstone for the development of DNA-based electrochemical sensors.

She was awarded the National Medal of Science by Barack Obama in 2011, “For discovery of a new property of the DNA helix, long-range electron transfer, and for showing that electron transfer depends upon stacking of the base pairs and DNA dynamics. Her experiments reveal a strategy for how DNA repair proteins locate DNA lesions and demonstrate a biological role for DNA-mediated charge transfer.”

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