Scientific progress in medicine and public health during the last century has been dominated by studies performed with groups of people. Today many people collect data their own data to help investigate a health problem, make progress towards a goal, or simply because we are curious. Such investigations need not be conducted on groups. Often, they involve just a single person who is both the subject and the investigator. They are “N-of-1” trials, where data are generated by the individual, normally making use of self-quantification systems, including mobile apps and portable monitoring devices. This focus theme of “Methods of Information in Medicine” on single subject research encourages submission of original articles describing data processing and research methods using a “N-of-1” design where the questions and analysis are guided by the interests and participation of the subject. We encourage submissions that focus on challenges and questions involving data collection, processing, integration, analysis and visualization in the context of single subject research.
EXAMPLE METHODS AND TECHNOLOGIES THAT ARE RELEVANT INCLUDE, BUT ARE NOT LIMITED TO:
IT infrastructures for Single-Subject-Research trials
Aggregating data from multiple sensors
Ontologies and knowledge representation
Integrating N-of-1 data with other clinical information systems (health records, decision support)
Data analysis and visualization
Data quality, metadata and annotation aspects
WE ENCOURAGE SUBMISSIONS IN THE FORM OF:
Original contributions of individual or a series of N-of-1 trial
Original contributions with Single Subject Research Design, Single Case Experimental Design or Patient Led Research Desig
Original contributions on methodological aspects of informatics and statistics applied to N-of-1 trial
Reviews in the field of Single Subject Research Design and data processing of patient generated dat
Perspective and opinion papers
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