Metabolic Mutations Help Bacteria Resist Drug Treatment
MIT researchers discovered bacteria is more susceptible to antibiotics when forced to burn more energy.
MIT researchers have now identified another class of mutations that helps bacteria develop resistance. In a study of E. coli, they discovered that mutations to genes involved in metabolism can also help bacteria to evade the toxic effects of several different antibiotics. The findings shed light on a fundamental facet of how antibiotics work, and suggest potential new avenues for developing drugs that could enhance the effectiveness of existing antibiotics, the researchers say.
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