“It’s unequivocally a landmark paper,” Datta said. “Although we’ve had access to receptors as molecules for a long time, no one’s ever actually seen with their eyes what it looks like when an odor binds to a receptor.”
The result goes a long way toward confirming how animals identify and discriminate among astronomical numbers of smells. It also sheds light on key principles of receptor activity that might have far-reaching implications — for the evolution of chemical perception, for our understanding of how other neurological systems and processes work, and for practical applications like the development of targeted drugs and insect repellents.
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