The automated fast-flow device, designed by the Pentelute Group to replace traditional stepwise synthesis via click chemistry, consists of seven modules including a central control computer, solution storage system, three HPLC pumps, three multiposition valves, heating elements, reaction zone, and a UV-vis detector — all controlled by a modular script in the Mechwolf programming environment.
The research team decided on the name Tiny Tides for two reasons: their robot makes peptides or oligonucleotides, and is a micro-scale synthesizer capable of rapid condition optimization and synthesis using a low amount of reagent and solvent, a comparatively tiny cost.
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