WiFiWire is provides a Wire (i2c) protocol able to communicate over AsyncUDP.
You can have your program use a Wire (i2c) sensor/device, but it is communicating over a network rather than wiring. There are server and client software.
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Python for Microcontrollers – Adafruit Daily — Python on Microcontrollers Newsletter: A New Arduino MicroPython Package Manager, How-Tos and Much More! #CircuitPython #Python #micropython @ThePSF @Raspberry_Pi
EYE on NPI – Adafruit Daily — EYE on NPI Maxim’s Himalaya uSLIC Step-Down Power Module #EyeOnNPI @maximintegrated @digikey