Dr. Kaitlyn Sadtler is an immunologist and bioengineer at the National Institute of Biomedical Imaging and Bioengineering who helped develop the first antibody test that could determine how many people had been infected with COVID-19.

From Herbert Irving Comprehensive Cancer Center at Columbia on YouTube

SARS-CoV2 infection caused a broad spectrum of clinical manifestations, and most of the infected population may only show mild respiratory symptoms or remain asymptomatic. To more accurately estimate the viral prevalence rate in the USA, Dr. Sadtler’s group, in summer 2020, enrolled 9,028 blood samples for anti-Spike and anti-RBD antibody (IgG, IgM, and IgA) testing via ELISA from 241,424 adult volunteers (ClinicalTrials.gov NCT04334954), who had not previously been diagnosed with COVID-19. They detected 4.6% undiagnosed seropositivity and estimated 4.8 undiagnosed cases for every diagnosed case, which indicated 16.8 million undiagnosed cases in summer 2020.

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